2013年12月8日星期日

polycystic kidney disease treatment options

Polycystic kidney disease (PKD) is an inherited disorder in which clusters of noncancerous, fluid-filled sacs (cysts) develop within the kidneys.The disease can be inherited in autosomal dominant and recessive forms.Both autosomal dominant and recessive polycystic kidney disease are conditions with severe associated morbidity and mortality.If you are diagnosed with autosomal dominant polycystic kidney disease (ADPKD), your GP will probably refer you to a renal consultant or a nephrologist (doctor who specialises in treating kidney conditions).
Recent advances in the understanding of the genetic and molecular pathogenesis of both ADPKD and ARPKD have resulted in new, targeted therapies designed to disrupt cell signaling pathways responsible for the abnormal cell proliferation, dedifferentiation, apoptosis, and fluid secretion characteristic of the disease:
High blood pressure:Controlling high blood pressure may delay the progression of the disease and slow further kidney damage.Two medications widely used to lower blood pressure in people with ADPKD are angiotensin-2 receptor blockers (ARBs) and angiotensin-converting enzyme (ACE) inhibitors
Complications of cysts:Rarely, when kidney cysts are causing severe pain or obstructing other organs or blood vessels, you may need to undergo surgery to drain the cysts.
Pain:In many cases of ADPKD, treating the underlying cause of pain, such as kidney stones or a UTI, will help relieve the painful symptoms.Often, the pain is mild and you can control it with over-the-counter medications containing acetaminophen.If you have symptoms of chronic (long-term) pain, you may be referred to a specialist pain clinic.Possible treatment options the clinic may provide include amitriptyline.
Bladder or kidney infections:Bladder or kidney infections. Prompt treatment of infections with antibiotics is necessary to prevent kidney damage.
Kidney failure:Kidney failure. If your kidneys lose their ability to remove wastes and extra fluids from your blood.There are currently two effective treatments that can be used on a long-term basis:
dialysis – a machine replicates the functions of your kidneys
kidney transplant – a kidney is removed from a donor and implanted into a patient

And other Kidney stones,Aneurysms.
http://www.pkdclinic.org/plus/search.php?kwtype=0&q=polycystic+kidney+disease+treatment+options&submit.x=23&submit.y=20&searchtype=title

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