Focal segmental glomerulosclerosis is scar tissue that forms in parts of the
kidney called glomeruli.The glomeruli serve as filters, helping rid the body of
unnecessary or harmful substances.Focal Segmental Glomerulosclerosis (FSGS) is a
kidney disease that involves the formation of scar tissue in the glomeruli.
“Sclerosis” meaning scarring and “glomerulo-” which are tiny filters that
filter circulating blood producing urine as an end-product. When these filters
are damaged they become scarred and are no longer able to filter blood
appropriately. “Focal” meaning that only some of the filters are damaged while
some are normal and “segmental” is included because often only parts of the
filters are scarred.The natural history of FSGS varies a great deal.
Glomerular damage produces two types of syndromes: the nephrotic syndrome and
the nephritic syndrome.The nephrotic syndrome is not a specific kidney disease
rather it occurs as a result of any disease that causes damage to the
kidney-filtering units.Nephrotic syndrome is commonly associated with
proteinuria, protein in the urine, which occurs in diseases such as diabetes,
amyloidosis, and membranous glomerulopathy.FSGS is a nephrotic syndrome due to
massive amounts of protein found in the urine.The nephritic syndrome is commonly
associated with hematuria, blood in the urine, which occurs in diseases such as
lupus nephritis, immunoglobulin A (IgA) nephropathy, and acute diffuse
proliferative glomerulonephritis.
The condition affects both children and adults.Men and boys are affected
slightly more often than women and girls, and it also occurs more often in
African Americans.Focal segmental glomerulosclerosis causes about 20 - 25% of
all cases of nephrotic syndrome .The cause of focal segmental glomerulosclerosis
is usually unknown.Known causes include:Heroin use,HIV,Inherited genetic
problems,Obesity,Reflux nephropathy (a condition in which urine flows backward
from the bladder to the kidney),Sickle cell disease.
Treatment:
1.Micro-Chinese Medicine Osmotherapy
2.Newest immunosuppressive agents
3.Stem Cell Therapy
4.Immune clearance
