The typical pathology of diabetic nephropathy is the glomerular basement membrane thickening, mesangial matrix increase, efferent arteries and afferent arterioles hyaline degeneration, the formation of capillary hemangioma. However, no specific early glomerular change, so biopsy for early diagnosis of diabetic nephropathy is unlikely. When a patient has a history of diabetes, and microalbuminuria symptoms, hematuria, hypertension, renal dysfunction, by biopsy to identify belongs diabetic nephropathy, or chronic kidney disease, or both.
Diabetes type Ⅰ biopsy indications
1, Proteinuria appeared five years after the diagnosis of diabetes, kidney acute onset, Urine appears red blood cells (especially acanthocyte) and cellular casts.
2, There was no diabetic retinopathy or neuropathy, there are other manifestations of systemic disease, angiotensin converting enzyme inhibitors or angiotensin receptor antagonist 2 to 3 months, the glomerular filtration rate greater extent than 30%.
Diabetes type Ⅱ biopsy indications
1, Appears difficult to diagnose proteinuria, kidney acute onset, Urine appears red blood cells (especially acanthocyte) and cellular casts.
2, Although no diabetic retinopathy, but can not rule out kidney disease, or other systemic disease manifestations, angiotensin converting enzyme inhibitors or angiotensin receptor antagonist 2 to 3 months, the glomerular filtration rate a drop of greater than 30%.
Diabetes type Ⅰ biopsy indications
1, Proteinuria appeared five years after the diagnosis of diabetes, kidney acute onset, Urine appears red blood cells (especially acanthocyte) and cellular casts.
2, There was no diabetic retinopathy or neuropathy, there are other manifestations of systemic disease, angiotensin converting enzyme inhibitors or angiotensin receptor antagonist 2 to 3 months, the glomerular filtration rate greater extent than 30%.
Diabetes type Ⅱ biopsy indications
1, Appears difficult to diagnose proteinuria, kidney acute onset, Urine appears red blood cells (especially acanthocyte) and cellular casts.
2, Although no diabetic retinopathy, but can not rule out kidney disease, or other systemic disease manifestations, angiotensin converting enzyme inhibitors or angiotensin receptor antagonist 2 to 3 months, the glomerular filtration rate a drop of greater than 30%.
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